SYNTHESIS AND ANTI-HIV ACTIVITY OF 6-SUBSTITUTED PURINE 2'-DEOXY-2'-FLUORORIBOSIDES

被引：10

作者：

MARUYAMA, T

UTZUMI, K

SATO, Y

RICHMAN, DD

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 1-3期

关键词：

D O I：

10.1080/15257779408013260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3',5'-Di-O-protected 6-chloropurine arabinoside 4b was treated with diethylaminosulfur trifluoride (DAST) and subsequently deprotected with pyridinium p-toluenesulfonate to give 6-chloropurine 2'-deoxy-2'-fluororiboside 6a. The displacement with nucleophile afforded the 6-substituted congener 6b-e. Treatment of 5'-O-protected 6-chloropurine arabinoside 3c with DAST gave lyxo-epoxide 7.

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页码：527 / 537

页数：11

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