SYNTHESIS AND SPIN-TRAPPING CHEMISTRY OF 5,5-DIMETHYL-2-(TRIFLUOROMETHYL)-1-PYRROLINE N-OXIDE

被引：24

作者：

JANZEN, EG

ZHANG, YK

ARIMURA, M

机构：

[1] OKLAHOMA MED RES FDN,FREE RAD BIOL & AGING RES PROGRAM,NATL BIOMED CTR SPIN TRAPPING & FREE RAD,OKLAHOMA CITY,OK 73104

[2] OKLAHOMA MED RES FDN,FREE RAD BIOL & AGING RES PROGRAM,OKLAHOMA MED RES FDN SPIN TRAP SOURCE,OKLAHOMA CITY,OK 73104

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 17期

关键词：

D O I：

10.1021/jo00122a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new five-membered ring nitrone, 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide (2-TFDMPO), is synthesized for the purpose of spin trapping in free radical biology. Most of the spin adducts of 2-TFDMPO are persistent, and EPR, ENDOR, and MS spectra can be obtained. A variety of radicals give characteristic spectral signatures, among which is a rare type of line width alternation pattern due to hindered rotation of the trifluoromethyl group.

引用

页码：5434 / 5440

页数：7

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