BRAIN-DERIVED NEUROTROPHIC FACTOR PROMOTES SURVIVAL AND BLOCKS NITRIC-OXIDE SYNTHASE EXPRESSION IN ADULT-RAT SPINAL MOTONEURONS AFTER VENTRAL ROOT AVULSION

被引：161

作者：

NOVIKOV, L ^{[1
]}

NOVIKOVA, L ^{[1
]}

KELLERTH, JO ^{[1
]}

机构：

[1] UMEA UNIV,DEPT ANAT,S-90187 UMEA,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1995年 / 200卷 / 01期

关键词：

SPINAL CORD; AXOTOMY; CELL DEATH; NEUROTROPHIC FACTORS; NITRIC OXIDE SYNTHASE; FAST BLUE;

D O I：

10.1016/0304-3940(95)12078-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

in adult spinal motoneurons, retrograde cell death is induced by ventral root avulsion. A lethal effect of nitric oxide has been implicated, since nitric oxide synthase (NOS) is expressed in the motoneurons destined to die. Our study investigates the effects of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) on the retrograde cell death and NOS expression of adult rat spinal motoneurons. Following ventral root avulsion and 4 weeks of continuous treatment, BDNF, but not CNTF, was found to prevent cell death and NOS expression in the lesioned motoneurons. This suggests a therapeutic potential for BDNF in the adult nervous system, possibly through blockage of nitric oxide synthesis.

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页码：45 / 48

页数：4

相关论文

共 26 条

[1] AXOTOMY INDUCES NADPH DIAPHORASE ACTIVITY IN NEONATAL BUT NOT ADULT MOTONEURONS [J].

CLOWRY, GJ .

NEUROREPORT, 1993, 5 (03) :361-364

[2] RETROGRADE AXONAL-TRANSPORT OF CILIARY NEUROTROPHIC FACTOR IS INCREASED BY PERIPHERAL-NERVE INJURY [J].

CURTIS, R ;

ADRYAN, KM ;

ZHU, Y ;

HARKNESS, PJ ;

LINDSAY, RM ;

DISTEFANO, PS .

NATURE, 1993, 365 (6443) :253-255

[3]

Davis S, 1993, Curr Opin Neurobiol, V3, P20, DOI 10.1016/0959-4388(93)90030-3

[4] THE NEUROTROPHINS BDNF, NT-3, AND NGF DISPLAY DISTINCT PATTERNS OF RETROGRADE AXONAL-TRANSPORT IN PERIPHERAL AND CENTRAL NEURONS [J].

DISTEFANO, PS ;

FRIEDMAN, B ;

RADZIEJEWSKI, C ;

ALEXANDER, C ;

BOLAND, P ;

SCHICK, CM ;

LINDSAY, RM ;

WIEGAND, SJ .

NEURON, 1992, 8 (05) :983-993

[5] NEUROTROPHIC FACTORS IN THE TREATMENT OF MOTOR-NEURON DISEASE AND TRAUMA [J].

DISTEFANO, PS .

EXPERIMENTAL NEUROLOGY, 1993, 124 (01) :56-59

[6] BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS BY MK-801 (DIZOCILPINE MALEATE) RESCUES MOTONEURONS IN DEVELOPING RATS [J].

GREENSMITH, L ;

MENTIS, GZ ;

VRBOVA, G .

DEVELOPMENTAL BRAIN RESEARCH, 1994, 81 (02) :162-170

[7] CILIARY NEUROTROPHIC FACTOR PREVENTS NEURONAL DEGENERATION AND PROMOTES LOW AFFINITY NGF RECEPTOR EXPRESSION IN THE ADULT-RAT CNS [J].

HAGG, T ;

QUON, D ;

HIGAKI, J ;

VARON, S .

NEURON, 1992, 8 (01) :145-158

[8] NEURONAL NADPH DIAPHORASE IS A NITRIC-OXIDE SYNTHASE [J].

HOPE, BT ;

MICHAEL, GJ ;

KNIGGE, KM ;

VINCENT, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2811-2814

[9] VENTRAL ROOT AVULSION - AN EXPERIMENTAL-MODEL OF DEATH OF ADULT MOTOR-NEURONS [J].

KOLIATSOS, VE ;

PRICE, WL ;

PARDO, CA ;

PRICE, DL .

JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 342 (01) :35-44

[10] NEUROTROPHIC AGENTS PREVENT MOTONEURON DEATH FOLLOWING SCIATIC-NERVE SECTION IN THE NEONATAL MOUSE [J].

LI, LX ;

OPPENHEIM, RW ;

LEI, M ;

HOUENOU, LJ .

JOURNAL OF NEUROBIOLOGY, 1994, 25 (07) :759-766