5-ALPHA-ANDROSTAN-3-ALPHA,17-BETA-DIOL IS A HORMONE - STIMULATION OF CAMP ACCUMULATION IN HUMAN AND DOG PROSTATE

被引：44

作者：

NAKHLA, AM

DING, VDH

KHAN, MS

ROMAS, NA

RHODES, L

SMITH, RG

ROSNER, W

机构：

[1] COLUMBIA UNIV, ST LUKES ROOSEVELT HOSP CTR, DEPT MED, NEW YORK, NY 10019 USA

[2] COLUMBIA UNIV, ST LUKES ROOSEVELT HOSP CTR, DEPT UROL, NEW YORK, NY 10019 USA

[3] COLUMBIA UNIV, COLL PHYS & SURG, RAHWAY, NJ 07065 USA

[4] MERCK SHARP & DOHME LTD, RAHWAY, NJ 07065 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1995年 / 80卷 / 07期

关键词：

D O I：

10.1210/jc.80.7.2259

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

5 alpha-Androstan-3 alpha,17 beta-diol (3 alpha-diol) is a well known metabolite of dihydrotestosterone (DHT) and the concentration of its glucuronide in serum is' looked upon as a marker of DHT activity in skin and prostate. The data in this communication show that 3 alpha-diol is a potent agonist of the human and canine prostatic SHBG-[SHBG receptor]. It causes a robust rise in intracellular cAMP within minutes; the 1/2 max. response occurs at a concentration equal to its concentration in male plasma. Estradiol is the only other agonist in this system. All other steroids that bind to SHBG are antagonists.

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页码：2259 / 2262

页数：4

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