A Simple Method to Prepare Aqueous Dispersion of Iron Oxide Nanoparticles and Their Biodistribution Study

被引:19
作者
Ahmd, M. [1 ]
Rashid, K. [2 ]
Nadeem, M. [4 ]
Masood, K. [1 ]
Ali, S. [3 ]
Nafees, M. [3 ]
Gull, N. [1 ]
Mumtaz-ul-Haq [1 ]
Ibrahim, N. [4 ]
Saeed, A. [4 ]
Qureshy, A. [1 ]
Aleem, F. [5 ]
Naseer, H. [1 ]
Mehmood, S. [1 ]
Hyder, S. W. [1 ]
机构
[1] Inst Nucl Med & Oncol INMOL, Med Phys, Lahore 54570, Pakistan
[2] Pakistan Council Sci & Ind Res PCSIR, Lahore 54600, Pakistan
[3] Govt Coll Univ, Dept Phys, Lahore 54000, Pakistan
[4] Univ Malaysia UTM, Phys Dept, Johar Bharo 81310, Malaysia
[5] Univ Engn & Technol, Phys Dept, Lahore 54920, Pakistan
关键词
Aqueous Dispersion; Biodistribution; Drug delivery; Labeling Efficiency; Nanoparticles;
D O I
10.1166/jcsb.2012.1021
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 [原子与分子物理]; 070304 [物理化学]; 081704 [应用化学]; 1406 [纳米科学与工程];
摘要
Nanomaterials are promising future tools for diagnosis and therapy of different cancer types. These particles have an ability to cross bio-physiological barriers in-vivo. However, various characteristics of these nanodrugs, such as their physical size, biocompatibility and toxicity, their biodynamics including uptake and clearance by and from any particular organ need to be very well known before their use as carriers for anticancer drug. In this work, we propose a method to synthesize iron oxide nanoparticles and to prepare their water based suspension of for intravenous administration. Further, their biodistribution routes have been studies under Single Photon Emission Computed Tomography (SPECT) after labeling them with radioisotope. Only water based suspensions are favorable for water soluble anticancer drug loading. Our results indicate promising labeling efficiency achieved with Tc-99m and longer blood retention time of our prepared nanoparticles suspension due to their very small size even without any external coating. These particles are also able to evade Reticulo-endothelial (RES) system without any surface modification, and can cross blood brain barrier. Effect of external magnetic field also indicates their promise for further use in cancer therapy through anticancer drug also with additional coatings as planned in future.
引用
收藏
页码:201 / 209
页数:9
相关论文
共 26 条
[1]
In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques [J].
Al Faraj, Achraf ;
Fauvelle, Florence ;
Luciani, Nathalie ;
Lacroix, Ghislaine ;
Levy, Michael ;
Cremillieux, Yannick ;
Canet-Soulas, Emmanuelle .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 :351-361
[2]
MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles [J].
Artemov, D ;
Mori, N ;
Okollie, B ;
Bhujwalla, ZM .
MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (03) :403-408
[4]
Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents [J].
Bae, Younsoo ;
Diezi, Thomas A. ;
Zhao, Anni ;
Kwon, Glen S. .
JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) :324-330
[5]
Labeling efficiency and biodistribution of Technetium-99m labeled nanoparticles: interference by colloidal tin oxide particles [J].
Banerjee, T ;
Singh, AK ;
Sharma, RK ;
Maitra, AN .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 289 (1-2) :189-195
[6]
Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles [J].
Banerjee, T ;
Mitra, S ;
Singh, AK ;
Sharma, RK ;
Maitra, A .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 243 (1-2) :93-105
[7]
Bradbury Michelle, 2005, Magn Reson Imaging Clin N Am, V13, P225, DOI 10.1016/j.mric.2005.03.008
[8]
Nanoparticles in cancer therapy and diagnosis [J].
Brigger, I ;
Dubernet, C ;
Couvreur, P .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651
[9]
Modified natural nanoparticles as contrast agents for medical imaging [J].
Cormode, David P. ;
Jarzyna, Peter A. ;
Mulder, Willem J. M. ;
Fayad, Zahi A. .
ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (03) :329-338
[10]
BIODISTRIBUTION OF POLY(BUTYL 2-CYANOACRYLATE) NANOPARTICLES IN RABBITS [J].
DOUGLAS, SJ ;
DAVIS, SS ;
ILLUM, L .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 34 (1-2) :145-152