IMMUNOREGULATORY EFFECTS OF OVINE TROPHOBLASTIN PROTEIN (OTP) - ALL 5 ISOFORMS SUPPRESS PHA-INDUCED LYMPHOCYTE-PROLIFERATION

被引：32

作者：

FILLION, C ^{[1
]}

CHAOUAT, G ^{[1
]}

REINAUD, P ^{[1
]}

CHARPIGNY, JC ^{[1
]}

MARTAL, J ^{[1
]}

机构：

[1] INRA,PHYSIOL ANAT STN,F-78350 JOUY EN JOSAS,FRANCE

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1991年 / 19卷 / 03期

关键词：

OVINE TROPHOBLASTIN PROTEIN; ISOFORMS; IMMUNOSUPPRESSION;

D O I：

10.1016/0165-0378(91)90038-R

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunosuppressive properties of ovine trophoblastin protein (oTP) isoforms purified to homogeneity by DEAE HPLC have been studied within and across species barriers by in vitro assays. It has been demonstrated that not only the classical oTP 1, but in fact all 5 isoforms, are immunosuppressive in a PHA-induced proliferation assay, whilst being ineffective on IL-2 dependent CTL-L2 cell replication. The significance of these findings is discussed.

引用

页码：237 / 249

页数：13

共 14 条

[1] CLONING AND EXPRESSION OF CDNA-ENCODING OVINE TROPHOBLASTIN - ITS IDENTITY WITH A CLASS-II ALPHA-INTERFERON [J].