PRODUCTION OF THE CYSTEINE PROTEINASE-INHIBITOR CYSTATIN-C BY RAT SERTOLI CELLS

被引：16

作者：

ESNARD, A

ESNARD, F

GUILLOU, F

GAUTHIER, F

机构：

[1] UNIV TOURS,CNRS,URA 1334,ENZYMOL & CHIM PROT LAB,2BIS BLVD TONNELLE,F-37032 TOURS,FRANCE

[2] INRA,PHYSIOL REPROD STN,CNRS,URA 1291,F-37380 MONNAIE,FRANCE

来源：

FEBS LETTERS | 1992年 / 300卷 / 02期

关键词：

CYSTATIN-C; TESTIS; SERTOLI CELL; RAT;

D O I：

10.1016/0014-5793(92)80180-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Sertoli cells of the rat testis produce cystatin C, a cysteine proteinase inhibitor. Primary culture of Sertoli cells secreted both unglycosylated and glycosylated forms of rat cystatin C. Despite the low concentration of cystatin C in rete testis fluid, equilibrium dissociation constants (K(i)) for the interaction between cystatin C and lysosomal cathepsins indicate that this molecule could be involved in the local regulation of testicular cysteine proteinase activity which may be necessary for spermatogenesis and spermiogenesis.

引用

页码：131 / 135

页数：5

共 28 条

[1] HUMAN CYSTATIN-C - ROLE OF THE N-TERMINAL SEGMENT IN THE INHIBITION OF HUMAN CYSTEINE PROTEINASES AND IN ITS INACTIVATION BY LEUKOCYTE ELASTASE [J].