PREPARATION AND ANTICANCER ACTIVITY OF 2 TRYPTAMINE DERIVED PLATINUM COMPLEXES

In search for new antitumor drugs with target specificity [4-[10-(1H-indol-3-yl)-4,7-dioxo-3,8-diazadecyl]-1,2-benzenediolato(2-)-O,O']bis(triphenylphosphine)platinum (3) and L-[4-(9-carboxy-10-(1H-indol-3-yl)-4,7-dioxo-3,8-diazadecyl]-1,2-benezenediolato(2-)-O,O']bis(triphenylphosphine)platinum methyl ester (4) were prepared by condensation of [4-(6-carboxy-4-oxo-3-azahexyl)-1,2-benezenediolato(2-)-O,O']-bis(triphenylphosphine)platinum (2) with tryptamine and tryptophane methyl ester, respectively. Compounds 3 and 4 were found to have cytotoxic activity against MDA-MB 231, a human breast cancer cell line, albeit in a somewhat lower effectiveness than that of the cis-diamminedichloroplatinum(II) drug.