2-AMINOETHYLMETHYL-SULFONE (AEMS) - A POTENT STIMULATOR OF ATP-DEPENDENT CALCIUM-UPTAKE

被引：8

作者：

LIEBOWITZ, SM

LOMBARDINI, JB

ALLEN, CI

机构：

[1] UNIV TEXAS, COLL PHARM, DIV MED CHEM, AUSTIN, TX 78712 USA

[2] TEXAS TECH UNIV, HLTH SCI CTR, DEPT PHARMACOL, LUBBOCK, TX 79430 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1986年 / 120卷 / 01期

关键词：

D O I：

10.1016/0014-2999(86)90648-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Retinal ATP-dependent calcium ion uptake is stimulated by a number of agents, but none are previously reported to be as potent as taurine. We have evaluated the effects of 2-aminoethylmethyl-sulfone (AEMS), thiomorpholine-1,1-dioxide (TMS), and N-methyl-thiomorpholine-1,1-dioxide (M-TMS) on calcium ion uptake. AEMS is twice as potent a stimulator of calcium ion uptake compared to taurine. TMS and M-TMS did not stimulate calcium ion uptake at concentrations up to 20 mM. These data demonstrate that the sulfonic acid moiety can be replaced by a methyl sulfone moiety for stimulation of ATP-dependent calcium ion uptake.

引用

页码：111 / 113

页数：3

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