Several established screening methods were evaluated to examine enzyme production and toxic-chemical-degrading ability of four wood-decay fungi, including Phanerochaete chrysosporium, Pleurotus ostreatus, Auricularia auriculajudae, and Lentinus edodes. A correlation among various measured parameters for each fungal strain was established. This correlation may be used as a basis to simplify screening programs for wood-decay fungi that are capable of degrading toxic organic compounds.