THE POTENT FREE-RADICAL SCAVENGER ALPHA-LIPOIC ACID IMPROVES MEMORY IN AGED MICE - PUTATIVE RELATIONSHIP TO NMDA RECEPTOR DEFICITS

被引：74

作者：

STOLL, S ^{[1
]}

HARTMANN, H ^{[1
]}

COHEN, SA ^{[1
]}

MULLER, WE ^{[1
]}

机构：

[1] CENT INST MENTAL HLTH,DEPT PSYCHOPHARMACOL,J5,D-68159 MANNHEIM,GERMANY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 04期

关键词：

AGING; ALPHA-LIPOIC ACID; COGNITION; HABITUATION IN THE OPEN FIELD; LEARNING; MEMORY; MOUSE; THIOCTIC ACID;

D O I：

10.1016/0091-3057(93)90204-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Alpha-Lipoic acid (alpha-LA) improved longer-term memory of aged female NMRI mice in the habituation in the open field test at a dose of 100 mg/kg body weight for 15 days. In a separate experiment, no such effect could be found for young mice. Alpha-LA alleviated age-related NMDA receptor deficits (B(max)) without changing muscarinic, benzodiazepine, and alpha2-adrenergic receptor deficits in aged mice. The carbachol-stimulated accumulation of inositol monophosphates was not changed by the treatment with alpha-LA. These results give tentative support to the hypothesis that alpha-LA improves memory in aged mice, probably by a partial compensation of NMDA receptor deficits. Possible modes of action of alpha-LA based on its free radical scavenger properties are discussed in relation to the membrane hypothesis of aging.

引用

页码：799 / 805

页数：7

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