A 14.4 KDA ACIDIC SUBUNIT OF HUMAN RNA-POLYMERASE-II WITH A PUTATIVE LEUCINE-ZIPPER

被引：16

作者：

ACKER, J ^{[1
]}

WINTZERITH, M ^{[1
]}

VIGNERON, M ^{[1
]}

KEDINGER, C ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,INSERM,U184,UNITE BIOL MOLEC & GENET,CNRS,F-67085 STRASBOURG,FRANCE

来源：

DNA SEQUENCE | 1994年 / 4卷 / 05期

关键词：

AMINO ACIDS; EUKARYOTES; HOMOLOGY; NUCLEOTIDES; SEQUENCE; TRANSCRIPTION;

D O I：

10.3109/10425179409020860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cDNA of a small subunit (hRPB14.4) of RNA polymerase II (or B) from HeLa cells has been cloned. A 127 residue peptide sequence (calculated molecular weight of 14 478; isoelectric point of 3.7) was deduced and compared to that of the homologous subunit of Saccharomyces cerevisiae polymerase (ABC23, encoded by the RPB6/RPO26 gene). About 50% of the total residues were found to be conserved between yeast and man, with the C-terminal two-third being the most conserved (72% identity). A putative leucine-zipper comprising four properly spaced leucine residues, but not preceded by a basic domain, was identified near the C-terminal end of both proteins.

引用

页码：329 / 331

页数：3

共 7 条

[1] COMPLEMENTARY-DNA SEQUENCING - EXPRESSED SEQUENCE TAGS AND HUMAN GENOME PROJECT [J].