SYNTHESIS OF OPTICALLY-ACTIVE ALPHA-(IMIDAZOL-1-YL, PURIN-9-YL OR URACIL-1-YL) PROPANOIC AND SUCCINIC ACID-DERIVATIVES

被引：19

作者：

BIRKETT, PR

KING, H

CHAPLEO, CB

EWING, DF

MACKENZIE, G

机构：

[1] UNIV HULL,SCH CHEM,KINGSTON HULL HU6 7RX,N HUMBERSIDE,ENGLAND

[2] HUMBERSIDE UNIV,KINGSTON HULL HU6 7RT,ENGLAND

[3] RECKITT & COLMAN PROD,DEPT MED CHEM,KINGSTON HULL HU8 7DS,ENGLAND

来源：

TETRAHEDRON | 1993年 / 49卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)80256-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient route is reported to chiral propanoic and succinic acid derivatives substituted in the alpha-position with adenine, hypoxanthine and uracil groups. These nucleic acid base derivatives are obtained in optically pure form by a procedure which starts from an amino acid as a convenient chiral synthon.

引用

页码：11029 / 11036

页数：8

共 20 条

[1] PURINES, PYRIMIDINES, AND GLYOXALINES .4. CYANOURACILS FROM AMINES AND AMINO-ACIDS
ATKINSON, MR
SHAW, G
WARRENER, RN
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1956, (NOV): : 4118 - 4123
[2] BIRKETT PR, 1991, SYNTHESIS-STUTTGART, P157
[3] APPROACH TO THE SYNTHESIS OF AN OPTICALLY-ACTIVE POLYNUCLEOTIDE ANALOG
LAN, MJ
OVERBERGER, CG
[J]. ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1988, 20 (03) : 261 - 269
[4] SYNTHESIS OF POLYURETHANES CONTAINING NUCLEIC-ACID BASE DERIVATIVES AS GRAFTED PENDANTS AND THEIR PRECURSOR AMINO FUNCTIONALIZED POLYURETHANE
LU, CX
YANG, Y
XIAO, CD
JI, AX
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1987, 25 (12) : 3267 - 3281
[5] SYNTHESIS OF POTENTIAL ANTICANCER AGENTS .9. 9-ETHYL-6-SUBSTITUTED-PURINES
MONTGOMERY, JA
TEMPLE, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (19) : 5238 - 5242
[6] CIRCULAR-DICHROISM OF POLYETHYLENIMINE CONTAINING OPTICALLY-ACTIVE THYMINE DERIVATIVES AS GRAFTED PENDANTS
OVERBERGER, CG
MORISHIMA, Y
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1980, 18 (04) : 1267 - 1277
[7] SYNTHESES OF POLYETHYLENIMINE CONTAINING ASYMMETRIC NUCLEIC-ACID BASE DERIVATIVES AS GRAFTED PENDANTS
OVERBERGER, CG
MORISHIMA, Y
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1980, 18 (04) : 1247 - 1265
[8] SYNTHESIS OF OPTICALLY-ACTIVE POLYNUCLEOTIDE ANALOGS WITH POLYVINYL ALCOHOL)S AS BACKBONES AND ADENINE AND 5-BROMOURACIL DERIVATIVES AS PENDANTS
OVERBERGER, CG
CHANG, JY
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1989, 27 (11) : 3589 - 3602
[9] SYNTHESIS OF OPTICALLY-ACTIVE POLYNUCLEOTIDE ANALOGS WITH POLYTRIMETHYLENIMINE BACKBONES AND THYMINE MOIETIES
OVERBERGER, CG
CHANG, JY
GUNN, VE
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1989, 27 (01) : 99 - 106
[10] SYNTHESIS OF POLYNUCLEOTIDE ANALOGS BY GRAFTING OPTICALLY-ACTIVE ADENINE, CYTOSINE, AND HYPOXANTHINE DERIVATIVES ONTO POLYTRIMETHYLENIMINE
OVERBERGER, CG
CHANG, JY
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1989, 27 (12) : 4013 - 4033

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