ANALYSIS OF P16 GENE DELETION AND POINT MUTATION IN BREAST-CARCINOMA

被引：30

作者：

QUESNEL, B

FENAUX, P

PHILIPPE, N

FOURNIER, J

BONNETERRE, J

PREUDHOMME, C

PEYRAT, JP

机构：

[1] CHU LILLE,SERV MALAD SANG,F-59037 LILLE,FRANCE

[2] INSERM,INST RECH CANC,U124,LILLE,FRANCE

[3] CTR OSCAR LAMBRET,F-59020 LILLE,FRANCE

[4] CHU LILLE,HEMATOL LAB,LILLE,FRANCE

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 72卷 / 02期

关键词：

BREAST CARCINOMA; P16; CELL CYCLE; TUMOR SUPPRESSOR; CDKN2;

D O I：

10.1038/bjc.1995.337

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We looked for p16 gene deletion by Southern analysis and p16 gene point mutation by single-stranded conformation polymorphism (SSCP) analysis and direct sequencing of DNA from fresh tumour samples of 35 and 33 breast carcinomas respectively. No homozygous p16 gene deletion was found in any case. A missense point mutation of the p16 gene was found in only one patient. This point mutation was absent from the patient's lymphocytes, ruling out a polymorphism or a germline mutation. These findings suggest that p16 gene alterations are rarely observed in breast carcinoma.

引用

页码：351 / 353

页数：3

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