SYNTHESIS OF THE PIPERIDINONE METABOLITES OF PIPERIDINE TYPE PHENOTHIAZINE ANTIPSYCHOTIC-DRUGS VIA RUTHENIUM TETROXIDE OXIDATION

被引：46

作者：

LIN, G

MIDHA, KK

HAWES, EM

机构：

[1] College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 02期

关键词：

D O I：

10.1002/jhet.5570280202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lactam metabolites of the piperidine type phenothiazine antipsychotic drugs thioridazine, mesoridazine and sulforidazine were synthesized in six steps from commercially available 2-(2-hydroxyethyl)piperidine. The key step involved ruthenium tetroxide oxidation of N-protected 2-(2-chloroethyl)piperidine. The products were then oxidized to obtain the phenothiazine ring 5-sulfoxide analogues.

引用

页码：215 / 219

页数：5

共 17 条

[1]

CARMOSIN RJ, 1987, Patent No. 4683239

[2] IDENTIFICATION IN MAN OF URINARY METABOLITES OF A NEW BRONCHODILATOR, MDL-257, USING TRIPLE STAGE QUADRUPOLE MASS-SPECTROMETRY MASS-SPECTROMETRY [J].