ACCELERATED HYPERTENSION AND NEPHROANGIOSCLEROSIS ASSOCIATED WITH ANTIPHOSPHOLIPID SYNDROME - REPORT OF 2 CASES AND REVIEW OF THE LITERATURE

被引：5

作者：

DURAND, JM

LEFEVRE, P

KAPLANSKI, G

CASANOVA, P

SOUBEYRAND, J

机构：

[1] Department of Internal Medicine, CHU Sainte-Marguerite, Marseille, Cedex 9, 13274

[2] Department of Pathology, CHU Timone, Marseille

来源：

CLINICAL RHEUMATOLOGY | 1994年 / 13卷 / 04期

关键词：

HYPERTENSION; NEPHROANGIOSCLEROSIS; THROMBOTIC MICROANGIOPATHY; LUPUS ANTICOAGULANT; ANTICARDIOLIPIN ANTIBODY; PRIMARY ANTIPHOSPHOLIPID SYNDROME;

D O I：

10.1007/BF02243009

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the interaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.

引用

页码：635 / 640

页数：6

共 36 条

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