PECAM-1 - ITS EXPRESSION AND FUNCTION AS A CELL-ADHESION MOLECULE ON HEMATOPOIETIC AND ENDOTHELIAL-CELLS

被引：112

作者：

WATT, SM

GSCHMEISSNER, SE

BATES, PA

机构：

[1] MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford

[2] ICRF Electron Microscopy Laboratory, London

[3] ICRF Biomolecular Modelling Laboratory, London

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 17卷 / 3-4期

关键词：

PECAM-1; CD31; CD34; HEMATOPOIETIC PROGENITOR CELLS; STEM CELLS; B CELL PRECURSORS; ENDOTHELIAL CELLS; HOMOTYPIC ADHESION; HETEROTYPIC ADHESION; HEPARAN SULFATE; CHONDROITIN SULFATE; GLYCOSAMINOGLYCANS; MONOCYTES; NEUTROPHILS; T AND B LYMPHOCYTES; GENE STRUCTURE AND FUNCTION;

D O I：

10.3109/10428199509056827

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PECAM-1, the platelet-endothelial cell adhesion molecule, is expressed on a variety of mature hemopoietic cell types (including neutrophils, monocytes and T cell subsets) and is also present on endothelia. In such cases, this glycoprotein functions as either a homotypic or heterotypic adhesion molecule contributing to cell migration, inflammatory processes and wound healing. We have recently shown that PECAM-1 is expressed on a variety of hemopoietic progenitor cell types and on stromal macrophages from human bone marrow. In this review, we discuss the possible functional significance of this molecule for both hemopoietic cell differentiation and for mature cells.

引用

页码：229 / 244

页数：16

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