Patient-specific pluripotent stem cells in doxorubicin cardiotoxicity: A new window into personalized medicine

被引：11

作者：

Bernstein, Daniel

Burridge, Paul

机构：

[1] Stanford Univ, Stanford Cardiovasc Inst, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Stanford Cardiovasc Inst, Dept Med, Stanford, CA 94305 USA

来源：

PROGRESS IN PEDIATRIC CARDIOLOGY | 2014年 / 37卷 / 1-2期

关键词：

Doxorubicin cardiotoxicity; Cardiomyocytes; Cancer; ROS; Stem cells;

D O I：

10.1016/j.ppedcard.2014.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

In the past ten years, there has been a revolution in our ability to generate human pluripotent stem cells (hiPSCs) from adult somatic cells. hiPSCs can be differentiated into many cell types, including cardiomyocytes (hiPSC-CMs), providing cardiovascular scientists for the first time with a human heart muscle cell line. hiPSC-CMs have several potential uses: to study mechanisms of disease, as a platform for screening drugs for efficacy and toxicity, and as cell therapy for diseases such as cardiomyopathy. In this review, we discuss the potential of using hiPSC-CMs for drug toxicity testing, and in particular to screen genetic variants found to be predictive of which patients develop cardiotoxicity after receiving the chemotherapeutic agent doxorubicin. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：23 / 27

页数：5

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