INVIVO ACTIVATION BY ULTRAVIOLET RAYS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT

被引：70

作者：

CAVARD, C

ZIDER, A

VERNET, M

BENNOUN, M

SARAGOSTI, S

GRIMBER, G

BRIAND, P

机构：

[1] Genetique et Pathologie Exp., ICGM 22, F-75014 Paris, Rue Mechain

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 86卷 / 04期

关键词：

HIV-1; keratinocytes; transgenic mice; UV;

D O I：

10.1172/JCI114849

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin β-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

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页码：1369 / 1374

页数：6

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