GLUCOSE-INFUSION ABOLISHES THE EXCESSIVE ATP DEGRADATION IN WORKING MUSCLES OF A PATIENT WITH MCARDLES DISEASE

被引：13

作者：

MINEO, I ^{[1
]}

KONO, N ^{[1
]}

YAMADA, Y ^{[1
]}

HARA, N ^{[1
]}

KIYOKAWA, H ^{[1
]}

HAMAGUCHI, T ^{[1
]}

KAWACHI, M ^{[1
]}

YAMASAKI, T ^{[1
]}

NAKAJIMA, H ^{[1
]}

KUWAJIMA, M ^{[1
]}

TARUI, S ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, DEPT INTERNAL MED 2, FUKUSHIMA KU, OSAKA 553, JAPAN

来源：

MUSCLE & NERVE | 1990年 / 13卷 / 07期

关键词：

ATP; exercise; glucose; hypoxanthine; McArdle's disease;

D O I：

10.1002/mus.880130710

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 23‐year‐old woman with McArdle' disease performed mild leg exercise on a bicycle ergometer. Saline or 10% glucose solution was infused throughout exercise. After exercise with saline infusion, her plasma concentration of ammonia, hypoxathine and creatine kinase increased greatly. Conversely, after exercise with glucose infusion, there were no appreciable changes in these plasma substances. In addition, she noticed that glucose infusion relieved her from muscle symptoms during exercise. These findings seggest that glucose infusion to patiets with McArdle' desease ameliorates excessive ATP degradation in exercising muscles. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：618 / 620

页数：3

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