STUDIES ON THE EFFECTS OF ANTIDEPRESSANT DRUGS ON THE ANTINOCICEPTIVE ACTION OF MORPHINE AND ON PLASMA MORPHINE IN RAT AND MAN

被引：87

作者：

VENTAFRIDDA, V ^{[1
]}

BIANCHI, M ^{[1
]}

RIPAMONTI, C ^{[1
]}

SACERDOTE, P ^{[1
]}

DECONNO, F ^{[1
]}

ZECCA, E ^{[1
]}

PANERAI, AE ^{[1
]}

机构：

[1] UNIV MILAN,DEPT PHARMACOL,I-20129 MILAN,ITALY

来源：

PAIN | 1990年 / 43卷 / 02期

关键词：

Analgesia; Antidepressants; Morphine;

D O I：

10.1016/0304-3959(90)91068-T

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In the rat we studied the effect of 3 tricyclic antidepressants: chlorimipramine, amitriptyline and nortriptyline, and the atypical antidepressant trazodone on pain thresholds when administered alone or together with morphine. Moreover, we evaluated the effect of the antidepressants on free morphine plasma concentrations both in the rat and in man. We observed that chlorimipramine and amitriptyline, two tricyclic antidepressants active on the serotoninergic system, induce analgesia and potentiate morphine analgesia in a dose-related fashion. The noradrenergic tricyclic nortriptyline and trazodone did not elicit analgesia and inconsistently affected morphine analgesia. In the rat, all drugs tested increased plasma concentrations of morphine with the exception of amitriptyline. In man, only chlorimipramine and amitriptyline increased the plasma concentration of the free opiate. © 1990.

引用

页码：155 / 162

页数：8

共 16 条

[1]

BEAUMENTO G, 1973, J INT MED RES, V18, P435

[2]

BIANCHI M, 1988, ARCH INT PHARMACOD T, V295, P34

[3] TRAZODONE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN DEPRESSION AND ANXIETY [J].