THE INVIVO INHIBITION OF TRANSPORT ENZYME-ACTIVITIES BY CHLOROQUINE IN DIFFERENT ORGANS OF RAT IS REVERSIBLE

被引：20

作者：

CHANDRA, S ^{[1
]}

ADHIKARY, G ^{[1
]}

SIKDAR, R ^{[1
]}

SEN, PC ^{[1
]}

机构：

[1] BOSE INST,DEPT CHEM,CALCUTTA 700009,W BENGAL,INDIA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1992年 / 118卷 / 01期

关键词：

NA+; K+-ATPASE; CA2+-ATPASE; FLUIDITY; CHLOROQUINE; MICROSOMAL MEMBRANES (RAT);

D O I：

10.1007/BF00249690

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The antimalarial drug chloroquine is found to inhibit Na+, K+-ATPase, Ca2+, Mg2+-ATPase, Ca2+-ATPase, pNPPase and acetylcholinesterase activities in different organs of rat in vivo when injected for a certain periods of time. The inhibition seems to be due to the changes in the level of phospholipid, cholesterol and the fatty acid of the lipid and the alteration of the fluidity of the microsomal membranes. However, the enzyme activities return to the normal level in about 2-3 weeks after the discontinuation of the drug suggesting that the drug effect is reversible.

引用

页码：15 / 21

页数：7

共 25 条

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