VASCULAR OXIDATIVE-METABOLISM UNDER DIFFERENT METABOLIC CONDITIONS

被引:9
作者
HARDIN, CD
WISEMAN, RW
KUSHMERICK, MJ
机构
[1] UNIV WASHINGTON, DEPT PHYSIOL, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT BIOPHYS, SEATTLE, WA 98195 USA
关键词
VASCULAR SMOOTH MUSCLE; CONTROL OF RESPIRATION; NMR; P-31; OXYGEN CONSUMPTION;
D O I
10.1016/0167-4889(92)90060-O
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Control of respiration in vascular smooth muscle was examined while the metabolic state of the tissue was manipulated. During KCl-induced contractures in the presence of 5 mM glucose, oxygen consumption increased by 10 nmol / per min g without any decrease in phosphocreatine (PCr) or ATP as determined by P-31-NMR indicating a control of respiration which does not involve changes in high-energy phosphates (e.g., ADP, phosphorylation potential). However, when aortae with resting tone in the absence of substrate were then provided with 5 mM 2-deoxyglucose as the sole substrate, oxygen consumption increased 7.4 nmol / min per g while PCr decreased by more than 50% (resulting in a 2-fold increase in the calculated free ADP) with no change in tension from resting tone. During a subsequent KCI induced contracture in the presence of 2-deoxyglucose, oxygen consumption increased an additional 7.2 nmol / min per g while PCr continued to decline. Therefore, at least two mechanisms of respiratory control may exist in sheep aorta, one dependent and the other independent of changes in high-energy phosphates.
引用
收藏
页码:133 / 141
页数:9
相关论文
共 30 条
[1]   NMR INVESTIGATIONS OF CELLULAR-ENERGY METABOLISM [J].
BALABAN, RS ;
KORETSKY, A ;
KATZ, L .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 508 :48-53
[2]   MITOCHONDRIAL REGULATION OF PHOSPHOCREATINE INORGANIC-PHOSPHATE RATIOS IN EXERCISING HUMAN-MUSCLE - A GATED P-31 NMR-STUDY [J].
CHANCE, B ;
ELEFF, S ;
LEIGH, JS ;
SOKOLOW, D ;
SAPEGA, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6714-6718
[3]   REACTION OF OXYGEN WITH RESPIRATORY CHAIN IN CELLS AND TISSUES [J].
CHANCE, B .
JOURNAL OF GENERAL PHYSIOLOGY, 1965, 49 (1P2) :163-&
[4]   HOW LARGE IS THE DROP IN PO-2 BETWEEN CYTOSOL AND MITOCHONDRION [J].
CLARK, A ;
CLARK, PAA ;
CONNETT, RJ ;
GAYESKI, TEJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (06) :C583-C587
[5]   REGULATION OF VO2 IN RED MUSCLE - DO CURRENT BIOCHEMICAL HYPOTHESES FIT INVIVO DATA [J].
CONNETT, RJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :R898-R906
[6]   ANALYSIS OF METABOLIC CONTROL - NEW INSIGHTS USING SCALED CREATINE-KINASE MODEL [J].
CONNETT, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (06) :R949-R959
[7]   CA-2+ TRANSPORT BY MAMMALIAN MITOCHONDRIA AND ITS ROLE IN HORMONE ACTION [J].
DENTON, RM ;
MCCORMACK, JG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (06) :E543-E554
[8]   CA-2+ AS A 2ND MESSENGER WITHIN MITOCHONDRIA OF THE HEART AND OTHER TISSUES [J].
DENTON, RM ;
MCCORMACK, JG .
ANNUAL REVIEW OF PHYSIOLOGY, 1990, 52 :451-466
[9]   HOMEOSTATIC REGULATION OF CELLULAR ENERGY-METABOLISM - EXPERIMENTAL CHARACTERIZATION INVIVO AND FIT TO A MODEL [J].
ERECINSKA, M ;
WILSON, DF ;
NISHIKI, K .
AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 234 (03) :C82-C89
[10]   PROTON ELECTROCHEMICAL GRADIENTS AND ENERGY-TRANSDUCTION PROCESSES [J].
FERGUSON, SJ ;
SORGATO, MC .
ANNUAL REVIEW OF BIOCHEMISTRY, 1982, 51 :185-217