TESTING FOR LINKAGE - PHASE KNOWN/UNKNOWN

被引:3
作者
DOERGE, RW
机构
[1] Biometrics Unit, 337 Warren Hall, Cornell University, Ithaca
关键词
D O I
10.1093/oxfordjournals.jhered.a111528
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
It has been well established in human genetics that when one is testing for linkage between two loci, the significance test must be one-sided for the purpose of reflecting the theoretical limits placed on the estimated recombination fraction. However, the issue becomes obscure when phase known/- unknown data are considered. This paper presents the subtle difference in hypotheses for testing linkage between two loci when data from which one estimates recombination fractions is phase known or phase unknown. It is shown that a one-sided significance test is appropriate for phase-known data, while a two-sided significance test is correct for phase-unknown data.
引用
收藏
页码:61 / 62
页数:2
相关论文
共 9 条
[1]  
Bailey NTJ., 1961, INTRO MATH THEORY GE
[2]   GENETIC-LINKAGE OF THE PHYTOPHTHORA RESISTANCE GENE RPS2 AND THE NODULATION RESPONSE GENE RJ2 IN SOYBEAN [J].
DEVINE, TE ;
KILEN, TC ;
ONEILL, JJ .
CROP SCIENCE, 1991, 31 (03) :713-715
[3]   GENETIC-LINKAGE TESTS FOR THE RJ4 GENE IN SOYBEAN [J].
DEVINE, TE .
CROP SCIENCE, 1992, 32 (04) :961-964
[4]   GENETIC-LINKAGE OF THE RJ2 GENE IN SOYBEAN [J].
DEVINE, TE ;
ONEILL, JJ ;
KIANG, YT ;
BULT, CJ .
CROP SCIENCE, 1991, 31 (03) :665-668
[5]  
DOERGE RW, 1993, THESIS N CAROLINA ST
[6]   GENETIC AND LINKAGE ANALYSIS OF ACONITATE HYDRATASE VARIANTS IN SOYBEAN [J].
KIANG, YT ;
BULT, CJ .
CROP SCIENCE, 1991, 31 (02) :322-325
[7]  
Mather K, 1963, MEASUREMENT LINKAGE
[8]  
MEAD D, 1991, MAIZE GENET COOP NEW, V65, P103
[9]  
OTT J, 1991, ANAL HUMAN GENETIC L