NEW POLYMERIC HYDROGEL FORMULATIONS FOR THE CONTROLLED RELEASE OF ALPHA-INTERFERON

被引：23

作者：

CHIELLINI, E ^{[1
]}

SOLARO, R ^{[1
]}

LEONARDI, G ^{[1
]}

GIANNASI, D ^{[1
]}

LISCIANI, R ^{[1
]}

MAZZANTI, G ^{[1
]}

机构：

[1] ISI SPA,CASTELVECCHIO PASCOLI LUC,ITALY

来源：

JOURNAL OF CONTROLLED RELEASE | 1992年 / 22卷 / 03期

关键词：

POLYMERIC PARTIAL ESTERS; MALEIC ANHYDRIDE-ALKYL VINYL ETHERS COPOLYMERS; PROTEIN RELEASE; ALPHA-INTERFERON; POLYMER-DRUG DEVICES;

D O I：

10.1016/0168-3659(92)90102-W

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combinations of partial esters of alternating maleic anhydride/mono-methoxyoligoethyleneglycol vinyl ethers copolymers with human serum albumin have been found suitable to give transparent, flexible and coherent films that display a marked hydrogel character and safely pass preliminary "in vitro" and "in vivo" toxicity tests. They have been used in the fabrication of polymeric inserts containing alpha-interferon (IFN(alpha)) by a low temperature casting procedure. Water uptake, dissolution levels, and kinetic release profiles of the active principle from inserts are presented and analyzed in terms of the different extent of hydrophilic interactions of proteins with the synthetic component in the hybrid polymer matrices.

引用

页码：273 / 282

页数：10

共 24 条

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