Immunomodulation by Pycnogenol(R) in retrovirus-infected or ethanol-fed mice

被引:14
作者
Cheshier, JE [1 ]
ArdestaniKaboudanian, S [1 ]
Liang, BL [1 ]
Araghiniknam, M [1 ]
Chung, SB [1 ]
Lane, L [1 ]
Castro, A [1 ]
Watson, RR [1 ]
机构
[1] UNIV ARIZONA, DEPT FAMILY & COMMUNITY MED, TUCSON, AZ 85724 USA
关键词
pycnogenol; immune dysfunction; ethanol-fed mice; retrovirus-infected mice;
D O I
10.1016/0024-3205(95)02303-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Pycnogenol(R) is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanol-fed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.
引用
收藏
页码:PL87 / PL96
页数:10
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