DRUG-PROTEIN CONJUGATES .14. MECHANISMS OF FORMATION OF PROTEIN-ARYLATING INTERMEDIATES FROM AMODIAQUINE, A MYELOTOXIN AND HEPATOTOXIN IN MAN

被引：106

作者：

MAGGS, JL ^{[1
]}

TINGLE, MD ^{[1
]}

KITTERINGHAM, NR ^{[1
]}

PARK, BK ^{[1
]}

机构：

[1] UNIV LIVERPOOL, DEPT PHARMACOL & THERAPEUT, LIVERPOOL L69 3BX, ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1988年 / 37卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0006-2952(88)90733-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：303 / 311

页数：9

共 50 条

[1]

ALBANO E, 1985, MOL PHARMACOL, V28, P306

[2] DISPOSITION AND METABOLISM OF AMODIAQUINE IN SMALL MAMMALS [J].

BARROW, A .

XENOBIOTICA, 1974, 4 (11) :669-680

[3] PARACETAMOL OXIDATION - SYNTHESIS AND REACTIVITY OF N-ACETYL-P-BENZOQUINONEIMINE [J].

BLAIR, IA ;

BOOBIS, AR ;

DAVIES, DS ;

CRESP, TM .

TETRAHEDRON LETTERS, 1980, 21 (51) :4947-4950

[4] AMINOALKYLPHENOLS AS ANTIMALARIALS .2. (HETEROCYCLIC-AMINO)-ALPHA-AMINO-O-CRESOLS - THE SYNTHESIS OF CAMOQUIN [J].

BURCKHALTER, JH ;

TENDICK, FH ;

JONES, EM ;

JONES, PA ;

HOLCOMB, WF ;

RAWLINS, AL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (04) :1363-1373

[5] ISOLATION, CHARACTERIZATION AND STANDARDIZATION OF A MAJOR METABOLITE OF AMODIAQUINE BY CHROMATOGRAPHIC AND SPECTROSCOPIC METHODS [J].

CHURCHILL, FC ;

MOUNT, DL ;

PATCHEN, LC ;

BJORKMAN, A .

JOURNAL OF CHROMATOGRAPHY, 1986, 377 :307-318

[6] SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN [J].

DAHLIN, DC ;

NELSON, SD .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :885-886

[7] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].

DAHLIN, DC ;

MIWA, GT ;

LU, AYH ;

NELSON, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331

[8]

EASTMOND DA, 1986, MOL PHARMACOL, V30, P674

[9] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J].

GILLETTE, JR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) :2785-2794

[10]

GRISHAM MB, 1984, J BIOL CHEM, V259, P404

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