PERTUSSIS TOXIN ENHANCES THE BETA-ADRENERGIC AND BLOCKS THE ALPHA2-ADRENERGIC REGULATION OF RENIN SECRETION IN RENAL CORTICAL SLICES

被引：6

作者：

PEDRAZACHAVERRI, J

ALATORREGONZALEZ, MC

PENA, JC

GARCIASAINZ, JA

机构：

[1] NATL AUTONOMOUS UNIV MEXICO, INST FIS CELULAR, DEPT BIOENERGET, APARTADO POSTAL 70-600, MEXICO CITY 04510, DF, MEXICO

[2] INST NACL NUTR SALVADOR ZUBIRAN, DEPT NEFROL & METAB MINERAL, MEXICO CITY 14000, DF, MEXICO

来源：

LIFE SCIENCES | 1986年 / 38卷 / 11期

关键词：

D O I：

10.1016/0024-3205(86)90234-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The adrenergic regulation of renin secretion was studied in renal cortical slices from control and pertussis toxin-treated rats. Pertussis toxin was used to study the role of adenylate cyclase in the control of renin release. It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group. Pertussis toxin: (a) increased significantly basal renin secretion, (b) displaced to the left the concentraiton-response curve for isoproterenol and epinephrine and magnified the response to epinephrine and (c) abolished the inhibitory effect of clonidine on renin secretion. This work confirms our previous results obtained in vivo and suggests a direct effect of pertussis toxin on the cells that secrete renin.

引用

页码：1005 / 1011

页数：7

共 27 条

[1]

BOYER JL, 1984, J BIOL CHEM, V259, P8076

[2] SEPARATE AND COMBINED EFFECTS OF OUABAIN AND EXTRACELLULAR POTASSIUM ON RENIN SECRETION FROM RAT RENAL CORTICAL SLICES [J].

CHURCHILL, MC ;

CHURCHILL, PC .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 300 (MAR) :105-114

[3]

CHURCHILL PC, 1980, J PHARMACOL EXP THER, V214, P541

[4]

CHURCHILL PC, 1980, J PHARMACOL EXP THER, V213, P144

[5] EFFECT OF DILTIAZEM, A CALCIUM-ANTAGONIST, ON RENIN SECRETION FROM RAT-KIDNEY SLICES [J].

CHURCHILL, PC ;

MCDONALD, FD ;

CHURCHILL, MC .

LIFE SCIENCES, 1981, 29 (04) :383-389

[6] POSSIBLE MECHANISM OF THE INHIBITORY EFFECT OF OUABAIN ON RENIN SECRETION FROM RAT RENAL CORTICAL SLICES [J].

CHURCHILL, PC .

JOURNAL OF PHYSIOLOGY-LONDON, 1979, 294 (SEP) :123-134

[7] ISOPROTERENOL-STIMULATED RENIN SECRETION IN THE RAT - 2ND MESSENGER ROLES OF CA AND CYCLIC-AMP [J].

CHURCHILL, PC ;

CHURCHILL, MC .

LIFE SCIENCES, 1982, 30 (15) :1313-1319

[8]

CHURCHILL PC, 1979, J PHARMACOL EXP THER, V211, P615

[9] PERTUSSIS TOXIN BLOCKS THE SOMATOSTATIN-INDUCED INHIBITION OF GROWTH-HORMONE RELEASE AND ADENOSINE-3',5'-MONOPHOSPHATE ACCUMULATION [J].

CRONIN, MJ ;

ROGOL, AD ;

MYERS, GA ;

HEWLETT, EL .

ENDOCRINOLOGY, 1983, 113 (01) :209-215

[10] ROLE OF PHOSPHATIDYLINOSITOL TURNOVER IN ALPHA1 AND OF ADENYLATE-CYCLASE INHIBITION IN ALPHA2 EFFECTS OF CATECHOLAMINES [J].

FAIN, JN ;

GARCIASAINZ, JA .

LIFE SCIENCES, 1980, 26 (15) :1183-1194

← 1 2 3 →