REDUCED CELLULAR IMMUNE REACTIVITY IN HEALTHY-INDIVIDUALS DURING THE MALARIA TRANSMISSION SEASON

被引：33

作者：

THEANDER, TG

HVIID, L

ABUZEID, YA

ABDULHADI, NH

SAEED, BO

JAKOBSEN, PH

REIMERT, CM

JEPSEN, S

BAYOUMI, RAL

JENSEN, JB

机构：

[1] UNIV COPENHAGEN,INST MED MICROBIOL,DK-1168 COPENHAGEN,DENMARK

[2] MALARIA RES LAB,COPENHAGEN,DENMARK

[3] BRIGHAM YOUNG UNIV,DEPT MICROBIOL,PROVO,UT 84602

[4] WHO,NATL MALARIA DIAGNOST CTR,STATE SERUM INST,COPENHAGEN,DENMARK

[5] UNIV KHARTOUM,DEPT BIOCHEM,KHARTOUM,SUDAN

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

关键词：

Epidemiology; Immunosuppression; Lymphocyte; Malaria; Plasmodium falciparum;

D O I：

10.1016/0165-2478(90)90121-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin. © 1990.

引用

页码：237 / 242

页数：6

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