INCREASE IN BASIC FIBROBLAST GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN RAT-BRAIN AFTER FOREBRAIN ISCHEMIA

被引：99

作者：

KIYOTA, Y ^{[1
]}

TAKAMI, K ^{[1
]}

IWANE, M ^{[1
]}

SHINO, A ^{[1
]}

MIYAMOTO, M ^{[1
]}

TSUKUDA, R ^{[1
]}

NAGAOKA, A ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,BIOTECHNOL RES LABS,OSAKA 532,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; IMMUNOHISTOCHEMISTRY; FOREBRAIN ISCHEMIA; HIPPOCAMPUS; CAUDATE PUTAMEN; RAT;

D O I：

10.1016/0006-8993(91)91307-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using immunohistochemical techniques, a study was conducted to determine whether basic fibroblast growth factor (bFGF) is generated as one of the 'self-repair' responses in rat brain following transient forebrain ischemia. In normal brain, slight bFGF-like immunoreactivity was observed. However, in rats exposed to 20 min of forebrain ischemia, intense bFGF-like immunoreactivity was observed in the CA1 subfield of the hippocampus and the caudate putamen, and marked activity was evident in the temporal cortex, corpus callosum and the CA4 subfield of the hippocampus. Marked neuronal degeneration was also observed in these brain regions following forebrain ischemia. These results suggest that induction of bFGF-like immunoreactivity may be related to the healing which follows brain ischemia.

引用

页码：322 / 328

页数：7

共 24 条

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