INDUCTION OF DIFFERENTIATION OF HUMAN LEUKEMIA-CELLS BY INHIBITORS OF MYOSIN LIGHT CHAIN KINASE

被引：25

作者：

MAKISHIMA, M ^{[1
]}

HONMA, Y ^{[1
]}

HOZUMI, M ^{[1
]}

SAMPI, K ^{[1
]}

HATTORI, M ^{[1
]}

MOTOYOSHI, K ^{[1
]}

机构：

[1] NATL DEF MED COLL,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

FEBS LETTERS | 1991年 / 287卷 / 1-2期

关键词：

DIFFERENTIATION; MYOSIN LIGHT CHAIN KINASE; ML-9; ML-7; LEUKEMIA CELL; U937; CELL; HL-60;

D O I：

10.1016/0014-5793(91)80044-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-H-1-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-H-1-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three analogs of ML-9, which are an inhibitor and an activator of protein kinase C, and a calmodulin antagonist, respectively, did not induce differentiation of the cells.

引用

页码：175 / 177

页数：3

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