SIMULTANEOUS DETERMINATION OF PHENYLPROPANOLAMINE HYDROCHLORIDE AND ISOPROPAMIDE IN CAPSULE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING CROWNPAK COLUMN

被引：8

作者：

AHMED, AEHN

机构：

[1] Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut

来源：

ANALYTICAL LETTERS | 1993年 / 26卷 / 06期

关键词：

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; CROWNPAK COLUMN; PHENYLPROPANOLAMINE HC1; ISOPROPAMIDE;

D O I：

10.1080/00032719308019894

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procedure is described for the assay of phenylpropanolamine hydrochloride & isopropamide by HPLC using CROWNPAK column and detection at 200 nm. The system was aqueous perchloric acid as mobile phase containing 5% methanol. Linearity studies were carried out using peak height measurements. There was > 99% recovery and coefficient of variation was < 2% for formulation. The procedure was rapid, accurate, precise and specific for the assay of phenylpropanolamine HCl in presence of isopropamide.

引用

页码：1153 / 1162

页数：10

共 19 条

[1]

ABDELHAY MH, 1988, J PHARM SCI, V2, P135

[2]

ABUIRJEIE MA, 1989, ANAL LETT, V22, P365

[3] ANALYSIS OF PHENYLEPHRINE AND PHENYLPROPANOLAMINE HYDROCHLORIDES IN COMBINATION [J].