FEMALE PREPONDERANCE FOR LISINOPRIL-INDUCED COUGH IN HYPERTENSION

被引：63

作者：

OS, I

BRATLAND, B

DAHLOF, B

GISHOLT, K

SYVERTSEN, JO

TRETLI, S

机构：

[1] Department of Medicine (IO), Ullev and l University Hospital, Oslo

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 11期

关键词：

COUGH; FEMALE; HYPERTENSION; LISINOPRIL; NIFEDIPINE; SIDE EFFECT;

D O I：

10.1093/ajh/7.11.1012

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In a double-blind double-dummy multicenter study, patients with mild to moderate essential hypertension were randomized to receive either nifedipine (n = 416, 47.6% women) or lisinopril (n = 412, 50% women), and side effects were registered by specific questioning, by spontaneous reports, and by use of visual analog scales. Cough was spontaneously reported to occur in 8.5% with lisinopril compared to 3.1% with nifedipine. Women treated with lisinopril reported cough spontaneously three times more often than men, 12.6% v 4.4%, whereas no differences between the sexes were observed during the placebo period or during nifedipine treatment. Similar gender differences were observed during specific questioning. Furthermore, nonsmokers reported an increase in cough more often than did smokers.

引用

页码：1012 / 1015

页数：4

共 21 条

[1]

Lancaster S.G., Todd P.A., Lisinopril. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in hypertension and congestive heart failure, Drugs, 35, pp. 646-669, (1988)

[2]

Os I., Bratland B., Dahlof B., Et al., Lisinopril or nifedipine in essential hypertension?, J Hypertens, 9, pp. 1097-1104, (1991)

[3]

Coulter D.M., Edwards I.R., Cough associated with cap- topril and enalapril, Br Med J, 294, pp. 1521-1523, (1987)

[4]

Goldzer R.C., Lilly L.S., Solomon H.S., Prevalence of cough during angiotensin-converting enzyme inhibitor therapy, Am J Med, 85, (1988)

[5]

Town G.I., Hallwright G.P., Maling T.J., O'Donnell T.V., Angiotensin converting enzyme inhibitors and cough, N Z J Med, 100, pp. 161-163, (1987)

[6]

Ogihara T., Kaneko Y., Ikeda M., Et al., Clinical evaluation of delapril in Japan, Am J Hypertens, 4, pp. 425-435, (1991)

[7]

Sebastian J.L., McKinney W.P., Kaufman J., Young M.J., Angiotensin-converting enzyme inhibitors and cough. Prevalence in an outpatient medical clinic population, Chest, 99, pp. 36-39, (1991)

[8]

Fuller R.W., Cough associated with angiotensin-converting enzyme inhibitors, J Hum Hypertens, 3, pp. 159S-160S, (1989)

[9]

Strocchi E., Malini P.L., Valtancoli G., Et al., Cough during treatment with angiotensin converting enzyme inhibitors, Drug Invest, 4, pp. 69-72, (1992)

[10]

Gilchrist N.L., Richards A.M., March R., Nicholls M.G., Effect of sulindac on angiotensin converting enzyme inhibitor-induced cough: Randomised placebo- controlled double-blind cross-over study, J Hum Hypertens, 3, pp. 451-455, (1989)

← 1 2 3 →