ACUTE OTITIS-MEDIA IN CHILDREN - A STUDY OF NASOPHARYNGEAL CARRIAGE OF POTENTIAL PATHOGENS AND THERAPEUTIC EFFICACY OF CEFIXIME AND AMOXICILLIN-CLAVULANATE

被引：8

作者：

BOULESTEIX, J

BEGUE, P

DUBREUIL, C

MEGRAUD, F

DABERNAT, H

GESLIN, P

DELAROCQUE, F

TRINH, A

机构：

[1] HOP ENFANTS ARMAND TROUSSEAU,SERV PEDIAT & URGENCES PEDIAT,F-75571 PARIS 12,FRANCE

[2] CHU LYON SUD,SERV ORL,F-69495 PIERRE BENITE,FRANCE

[3] HOP PELLEGRIN,CHU BORDEAUX,BACTERIOL LAB,F-33076 BORDEAUX,FRANCE

[4] HOP PURPAN,CHU TOULOUSE,CENT MICROBIOL LAB,F-31059 TOULOUSE,FRANCE

[5] CHI CRETEIL,MICROBIOL LAB,F-94010 CRETEIL,FRANCE

[6] ACTIV,F-94100 ST MAUR FOSSES,FRANCE

[7] BELLON,F-92200 NEUILLY SUR SEINE,FRANCE

来源：

INFECTION | 1995年 / 23卷

关键词：

D O I：

10.1007/BF01742989

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

We conducted a large, multicenter, randomized, open-label study throughout France comparing the efficacy and safety of cefixime suspension (8 mg/kg/day, b. i. d., for 10 days) versus amoxicillin-clavulanate suspension (80 mg/kg/day, t. i. d., for 10 days) in 510 children (ages 6 to 36 months) with acute otitis media. The most frequent microorganisms colonizing the nasopharynx at the start of treatment were Streptococcus pneumoniae (51.5%), Haemophilus influenzae (45%) and Moraxella catarrhalis (30.2%). Rates of beta-lactamase positivity were 32.1% and 95.3% for H. influenzae and M. catarrhalis, respectively. Decreased susceptibility of S. pneumoniae to penicillin was found in 39.7% of isolates. Clinical efficacy was 87.8% (223/254) for cefixime and 87.0% (215/247) for amoxicillin-clavulanate. At the 5-week follow-up visit, relapse had occurred in 15.7% (31/197) of cefixime-treated patients and in 15.6% (32/205) of those treated with amoxicillin-clavulanate. We conclude that these two regimens are equally effective in acute otitis media in children.

引用

页码：S79 / S82

页数：4