ALTERATIONS IN THE ACTION-POTENTIAL OF APLYSIA NEURONS EVOKED BY A PHORBOLESTER ARE MEDIATED BY PROTEIN-KINASE-C

被引：2

作者：

PAPP, A ^{[1
]}

KLEE, MR ^{[1
]}

机构：

[1] MAX PLANCK INST BRAIN RES,DEPT NEUROPHYSIOL,D-60528 FRANKFURT,GERMANY

来源：

BRAIN RESEARCH | 1995年 / 684卷 / 01期

关键词：

APLYSIA; ACTION POTENTIAL; PROTEIN KINASE C; PHORBOL DIACETATE; H-7;

D O I：

10.1016/0006-8993(95)00437-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on the Aplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4 alpha-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation.

引用

页码：107 / 111

页数：5

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