THE IMPACT OF OSTEONECTIN FOR DIFFERENTIAL-DIAGNOSIS OF BONE-TUMORS - AN IMMUNOHISTOCHEMICAL APPROACH

被引:16
作者
BOSSE, A
VOLLMER, E
BOCKER, W
ROESSNER, A
WUISMAN, P
JONES, D
FISHER, LW
机构
[1] UNIV MUNSTER,ORTHOPAD KLIN,W-4400 MUNSTER,GERMANY
[2] NIH,INST DENT RES,BETHESDA,MD 20892
关键词
Differential diagnosis; Osteogenesis; Osteonectin; Osteosarcoma;
D O I
10.1016/S0344-0338(11)80229-3
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
75 osteosarcoma at various grades of histologic differentiation, including chondroblastic and small cell variants, and 5 fibrosarcomas of bone, 5 Ewing's sarcomas, 5 malignant fibrous histiocytomas of bone, 8 chondrosarcomas, and 2 dedifferentiated chondrosarcomas, were investigated immunohistochemically for evidence of osteonectin. According to the results of our study, osteonectin is present in all osteosarcomas, with special topographic preponderance in the osteoblastic and chondroblastic variants. Evidence of osteonection was also found in all other bone tumors we had analysed so far. In chondrosarcomas, positive reactions appeared only in the vicinity of trabeculae and in dedifferentiated areas. Thus, osteonectin cannot be regarded as a bone-specific protein. Although a high affinity for the osseous matrix is one of its undoubted features, it is therefore unsuitable for differential diagnostic purposes. © 1990, Gustav Fischer Verlag · Stuttgart · New York. All rights reserved.
引用
收藏
页码:651 / 657
页数:7
相关论文
共 28 条
  • [1] BONNUCCI E, 1986, CELL MEDIATED CALCIF, P33
  • [2] NEW MONOCLONAL-ANTIBODIES SPECIFIC FOR HUMAN SARCOMAS
    BRULAND, O
    FODSTAD, O
    FUNDERUD, S
    PIHL, A
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1986, 38 (01) : 27 - 31
  • [3] IMMUNOENZYMATIC LABELING OF MONOCLONAL-ANTIBODIES USING IMMUNE-COMPLEXES OF ALKALINE-PHOSPHATASE AND MONOCLONAL ANTI-ALKALINE PHOSPHATASE (APAAP COMPLEXES)
    CORDELL, JL
    FALINI, B
    ERBER, WN
    GHOSH, AK
    ABDULAZIZ, Z
    MACDONALD, S
    PULFORD, KAF
    STEIN, H
    MASON, DY
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1984, 32 (02) : 219 - 229
  • [4] FISHER LW, 1987, J BIOL CHEM, V262, P9702
  • [5] FISHER LW, 1985, CLIN ORTHOP RELAT R, V200, P362
  • [6] GRUNDBERG CM, 1984, METHOD ENZYMOL, V107, P526
  • [7] HERRING GM, 1961, BIOCHEM J, V81, pP5
  • [8] JUNDT G, 1987, CELL TISSUE RES, V248, P409
  • [9] IMMUNOCYTOCHEMICAL IDENTIFICATION OF OSTEOGENIC BONE-TUMORS BY OSTEONECTIN ANTIBODIES
    JUNDT, G
    SCHULZ, A
    BERGHAUSER, KH
    FISHER, LW
    GEHRONROBEY, P
    TERMINE, JD
    [J]. VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1989, 414 (04) : 345 - 353
  • [10] Price PA., 1983, BONE MINERAL RES ANN, V1, P157