SCREENING CHEMICALLY SYNTHESIZED PEPTIDE LIBRARIES FOR BIOLOGICALLY-RELEVANT MOLECULES

被引：48

作者：

GEYSEN, HM

MASON, TJ

机构：

[1] Chiron Mimotopes Pty Ltd, Clayton, Vic. 3168

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)80221-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Practical strategies for the synthesis and testing of large peptide libraries are described. The relationship between the number of monomers (amino acids) used to generate diversity and the magnitude of the synthesis and testing required is evaluated. Peptide optimization methods using strategies of replacement by non-natural and D-optical isomers are demonstrated.

引用

页码：397 / 404

页数：8

共 16 条

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