BOTCINOLIDE - A BIOLOGICALLY-ACTIVE NATURAL PRODUCT FROM BOTRYTIS-CINEREA

被引：36

作者：

CUTLER, HG

JACYNO, JM

HARWOOD, JS

DULIK, D

GOODRICH, PD

ROBERTS, RG

机构：

[1] OHIO NO UNIV, COLL PHARM, ADA, OH 45810 USA

[2] UNIV GEORGIA, DEPT CHEM, ATHENS, GA 30602 USA

[3] SMITH KLINE BEECHAM PHARMACEUT, DEPT DRUG METAB, KING OF PRUSSIA, PA 19406 USA

[4] USDA ARS, TREE FRUIT RES LAB, WENATCHEE, WA 98801 USA

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 11期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1271/bbb.57.1980

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel biologically active natural product was isolated from a strain of Botrytis cinerea found on cultivated raspberry fruit (Rubus ideaus) upon fermentation in a liquid medium. Following a bioassay-directed purification process, the final product was an amorphous solid with the molecular formula C20H34O8, and is trivially named botcinolide. It significantly inhibited etiolated wheat coleoptile growth at 10(-3) and 10(-4) M by 100 and 82% respectively, relative to the controls. Greenhouse-grown bean, corn, and tobacco plants were affected by treating with botcinolide, and exhibited chlorosis and severe necrosis at 10(-2) and 10(-3) M. The structure is a new hydroxylated nonalactone that is esterified with 4-hydroxy-2-octenoic acid.

引用

页码：1980 / 1982

页数：3

共 4 条

[1]

CUTLER HG, 1984, 11TH P ANN M PLANT G, P1

[2] EAST MALLING COLEOPTILE STRAIGHT GROWTH TEST METHOD [J].