THE ACTION OF 9 CHELATORS ON IRON-DEPENDENT RADICAL DAMAGE

被引:73
作者
DEAN, RT
NICHOLSON, P
机构
[1] Cell Biology Group, The Heart Research Institute, Camperdown, Sydney NSW 2050
关键词
FREE RADICALS; IRON; CHELATORS; PROTEIN OXIDATION; LIPID OXIDATION; METAL REDUCTION;
D O I
10.3109/10715769409147506
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nine iron chelators were tested in five systems for their effects on radical-generation and conversion at chelator: iron molar ratios from 0.1 to 10. Stimulatory actions might distinguish toxic from safer chelators. Radical-generating reactions which represent different aspects of iron (ferrous and ferric) availability were studied: a) the reaction with hydrogen peroxide to hydroxylate benzoate; b) the oxidation of ascorbate; c) the reaction with hydrogen peroxide to fragment proteins; d) the reaction with hydrogen peroxide to permit amplified chemiluminescence; and e) the induction of peroxidation of mitochondrial membrane lipids. The compounds used were HBED, CP130, Desferal, EDTA, pyridine-hydrazone (CGP 43'902B), Ferrozine, CP 94 (CGP 46'700), L1 (CGP 37 391) and rhodotorulic acid (CGP 45 274). Only the hexadentate compounds HBED, CP130 and Desferal were uniformly inhibitory (''protective''). The protective compounds were also apparently more stable during radical fluxes than the other chelators.
引用
收藏
页码:83 / 101
页数:19
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