EFFECTIVENESS OF 4 INTRAVENOUS IGG PREPARATIONS IN PREVENTION OF PHAGOCYTOSIS OF ANTI-RH-(D)-COATED ERYTHROCYTES BY MONONUCLEAR PHAGOCYTES

Four commercial intravenous immunoglobulin G (IGIV) preparations, Sandoglobulin (Sandoz), Intraglobin (Biotest), Gammonativ (Kabivitrum) and Gammaogard (Kabivitrum) showed percent inhibition of Fc receptor-mediated phagocytosis of anti-Rh(D)-coated erythrocytes as follows: 45+/-14 SD, 41+/-23 SD, 35+/-14 SD, 25+/-13 SD, respectively. Pre-incubation of Rh(D)-positive and antibody-coated Rh(D)-positive erythrocytes with IGIV did not lead to any inhibitory effects on phagocytosis. However, preincubation of mononuclear phagocytes with IGIV gave marked inhibition of phagocytosis of antibody-coated erythrocytes. In summary, all four IGIV preparations showed Fc receptor-mediated inhibition of phagocytosis of anti-Rh(D)-coated erythrocytes by mononuclear phagocytes.