THE LEADER POLYPEPTIDE OF THEILERS VIRUS IS ESSENTIAL FOR NEUROVIRULENCE BUT NOT FOR VIRUS GROWTH IN BHK CELLS

被引：28

作者：

CALENOFF, MA

BADSHAH, CS

DALCANTO, MC

LIPTON, HL

RUNDELL, MK

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL,CHICAGO,IL 60611

[2] NORTHWESTERN UNIV,SCH MED,DEPT PATHOL,CHICAGO,IL 60611

[3] EVANSTON HOSP CORP,DEPT NEUROL,EVANSTON,IL 60201

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 09期

关键词：

D O I：

10.1128/JVI.69.9.5544-5549.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

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页码：5544 / 5549

页数：6

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