PROMOTION BY SR-48692 OF GASTRIC-EMPTYING AND DEFECATION IN RATS SUGGESTING A ROLE OF ENDOGENOUS NEUROTENSIN

被引：12

作者：

CROCI, T

GIUDICE, A

MANARA, L

GULLY, D

LEFUR, G

机构：

[1] SANOFI RECH,F-31036 TOULOUSE,FRANCE

[2] SANOFI RECH,F-75008 PARIS,FRANCE

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 115卷 / 03期

关键词：

NEUROTENSIN; SR; 48692; RAT GUT; GASTRIC EMPTYING; DEFECATION;

D O I：

10.1111/j.1476-5381.1995.tb16343.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED(50) similar to 0.7 mu g kg(-1)) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.

引用

页码：383 / 384

页数：2

共 6 条

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