ANTIFUNGAL PROPERTIES OF TAXOL AND VARIOUS ANALOGS

被引：76

作者：

YOUNG, DH ^{[1
]}

MICHELOTTI, EL ^{[1
]}

SWINDELL, CS ^{[1
]}

KRAUSS, NE ^{[1
]}

机构：

[1] BRYN MAWR COLL,DEPT CHEM,BRYN MAWR,PA 19010

来源：

EXPERIENTIA | 1992年 / 48卷 / 09期

关键词：

TAXOL; ANTIFUNGAL; PHYTOPHTHORA-CAPSICI; NUCLEAR DIVISION; MICROTUBULES;

D O I：

10.1007/BF02118425

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The antimitotic agent taxol was tested for toxicity towards fungi from different taxonomic groups and found to be particularly active against oomycete fungi. In germinating zoospore cysts of the oomycete Phytophthora capsici the mechanism of action of taxol was shown to involve inhibition of mitosis, presumably resulting from an effect on microtubules. Various taxol analogues with deleted A-ring C-13 side chain substituents were tested for toxicity towards P. capsici and Aphanomyces cochlioides to provide insight into structural features required for activity. The importance of the side chain was shown by the much lower activity as compared to taxol of analogues lacking all or part of the side chain. The effect of stereochemistry at the C-2' position on fungitoxicity towards oomycetes was similar to that reported previously on mammalian microtubule assembly.

引用

收藏

页码：882 / 885

页数：4

相关论文

共 19 条

[1] TAXOL-INDUCED ANAPHASE REVERSAL - EVIDENCE THAT ELONGATING MICROTUBULES CAN EXERT A PUSHING FORCE IN LIVING CELLS [J].

BAJER, AS ;

CYPHER, C ;

MOLEBAJER, J ;

HOWARD, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (21) :6569-6573

[2] TAXOL, A MICROTUBULE STABILIZING AGENT, BLOCKS THE REPLICATION OF TRYPANOSOMA-CRUZI [J].

BAUM, SG ;

WITTNER, M ;

NADLER, JP ;

HORWITZ, SB ;

DENNIS, JE ;

SCHIFF, PB ;

TANOWITZ, HB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4571-4575

[3] DERIVATION AND PROPERTIES OF MICHAELIS-MENTEN TYPE AND HILL TYPE EQUATIONS FOR REFERENCE LIGANDS [J].

CHOU, TC .

JOURNAL OF THEORETICAL BIOLOGY, 1976, 59 (02) :253-276

[4]

DEBRABANDER M, 1981, P NATL ACAD SCI-BIOL, V78, P5608

[5] STUDIES ON NUTRITION OF PHYTOPHTHORA CRYPTOGEA [J].

ERWIN, DC ;

KATZNELSON, H .

CANADIAN JOURNAL OF MICROBIOLOGY, 1961, 7 (01) :15-&

[6] RELATIONSHIPS BETWEEN THE STRUCTURE OF TAXOL ANALOGS AND THEIR ANTIMITOTIC ACTIVITY [J].

GUERITTEVOEGELEIN, F ;

GUENARD, D ;

LAVELLE, F ;

LEGOFF, MT ;

MANGATAL, L ;

POTIER, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (03) :992-998

[7] THE EFFECT OF TAXOL ON LIVING EGGS OF XENOPUS-LAEVIS [J].

HEIDEMANN, SR ;

GALLAS, PT .

DEVELOPMENTAL BIOLOGY, 1980, 80 (02) :489-494

[8] TAXOL EFFECTS CYTOSKELETAL MICROTUBULES, FLAGELLA AND SPINDLE STRUCTURE OF THE CHRYSOFLAGELLATE ALGA POTERIOOCHROMONAS [J].

HERTH, W .

PROTOPLASMA, 1983, 115 (2-3) :228-239

[9] THE MICROTUBULE CYTOSKELETON IN HYPHAE OF UROMYCES-PHASEOLI GERMLINGS - ITS RELATIONSHIP TO THE REGION OF NUCLEATION AND TO THE F-ACTIN CYTOSKELETON [J].

HOCH, HC ;

STAPLES, RC .

PROTOPLASMA, 1985, 124 (1-2) :112-122

[10] RELATIONSHIPS BETWEEN THE STRUCTURES OF TAXOL AND BACCATINE-III DERIVATIVES AND THEIR INVITRO ACTION ON THE DISASSEMBLY OF MAMMALIAN BRAIN AND PHYSARUM AMEBAL MICROTUBULES [J].

LATASTE, H ;

SENILH, V ;

WRIGHT, M ;

GUENARD, D ;

POTIER, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :4090-4094