EXPRESSION OF EPSTEIN-BARR-VIRUS PROTEINS IN PRIMARY CNS LYMPHOMA IN AIDS PATIENTS

被引:45
作者
BASHIR, R
LUKA, J
CHELOHA, K
CHAMBERLAIN, M
HOCHBERG, F
机构
[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093
[2] UNIV NEBRASKA,MED CTR,DEPT PATHOLOGY,OMAHA,NE 68198
[3] MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114
关键词
D O I
10.1212/WNL.43.11.2358
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined the expression of the Epstein-Barr virus (EBV)-induced proteins (LMP [latent membrane protein], EBNA-2, and CD23) and a lytic protein, viral capsid antigen (VCA), in five acquired immune deficiency syndrome (AIDS)-related primary CNS lymphomas (PCNSLs). We compared that expression with the expression of the same proteins in PCNSL from six immunocompetent patients and severe combined immune deficiency (SCID) mouse brains injected with EBV-infected lymphoblastoid cell lines (LCLs). Brain biopsy tissue from an AIDS patient with progressive multifocal leukoencephalopathy (PML) and a normal brain was also studied. Three of the AIDS PCNSLs expressed both human immunoglobulin kappa and lambda light chains and two expressed lambda light chain only. All non-AIDS-related PCNSLs expressed a single light-chain isotype. All five AIDS-related PCNSLs expressed LMP-1 (>40%), EBNA-2 (>60%), and VCA (1 to 5%) of tumor cells. These proteins were similarly expressed in the SCID/human chimeras. None of the PCNSLs from immunocompetent subjects, the normal brain, or the brain of the patient with PML expressed these proteins. PCNSL in AIDS patients bears greater similarity to EBV-infected LCLs than to PCNSL from immunocompetent patients.
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页码:2358 / 2362
页数:5
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