USEFULNESS OF PARTIAL DISSECTION OF THE ZONA-PELLUCIDA IN A HUMAN INVITRO FERTILIZATION PROGRAM

被引：21

作者：

VANDERZWALMEN, P

BARLOW, P

NIJS, M

BERTIN, G

LEROY, F

SCHOYSMAN, R

机构：

[1] Fertility and IVF Unit, Van Helmont Hospital, 1800 Vilvoorde, Vaarstraat

[2] IVF Clinic and Human Reproduction Research Unit, Saint Pierre Hospital, Free University of Brussels, Brussels

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 04期

关键词：

ASSISTED FERTILIZATION; PARTIAL ZONA DISSECTION; IDIOPATHIC INFERTILITY; SEMEN PARAMETERS;

D O I：

10.1093/oxfordjournals.humrep.a137686

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The influence of partial zona dissection (PZD) on the fertilization rate was studied in 34 couples with a history of fertilization failure and/or severe sperm deficiency. Overall, PZD improved the rate of monospermic fertilization compared to controls (41/254 versus 6/111: P < 0.001) and fertilization was achieved in 50% of cases. However, the results differed according to the seminal characteristics. In 10 couples with at least two in-vitro fertilization (IVF) trials entailing total fertilization failure and with semen defined as normal, PZD did not significantly improve the monospermic fertilization rate (6/44 in the PZD group versus 2/39 among controls). A benefit related to PZD was evident in 33 attempts with severe sperm deficiency. In this group, only four of 72 unmanipulated control oocytes were fertilized but the monospermic fertilization rate was 14.6% for PZD oocytes. The rates of polyspermy were 40% and 14.6% in the groups with normal and abnormal semen parameters respectively. Of 33 trials with defective spermatozoa, 20 reached the stage of embryo transfer and three pregnancies were obtained, of which one aborted at 9 weeks.

引用

页码：537 / 544

页数：8

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