ENHANCEMENT OF ALCOHOL WITHDRAWAL CONVULSIONS IN MICE BY HALOPERIDOL

Although haloperidol has been used with a certain degree of success for treatment of acute alcohol abstinence, widespread use of haloperidol for treatment of alcohol withdrawal is cautioned against. In experimentally induced ethanol withdrawal, chlordiazepoxide appears to be a more effective and safer agent for ameliorating symptoms associated with excitation such as tremor, insomnia, anxiety and hyperexcitability. A double blind comparative clinical investigation between chlordiazepoxide and haloperidol for treatment of alcohol withdrawal is warranted.