SYNTHESES AND CONFORMATIONAL-ANALYSES OF SOME 3-AMINO-2,5-DIOXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE DERIVATIVES - X-RAY CRYSTAL-STRUCTURE OF 3S-3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-2,5-DIOXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE

被引：8

作者：

BALL, JB ^{[1
]}

WONG, MG ^{[1
]}

CAPUANO, B ^{[1
]}

GULBIS, JM ^{[1
]}

MACKAY, MF ^{[1
]}

ALEWOOD, PF ^{[1
]}

机构：

[1] LA TROBE UNIV,DEPT CHEM,BUNDOORA,VIC 3083,AUSTRALIA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 02期

关键词：

D O I：

10.1002/jhet.5570270231

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The constrained dipeptide mimic 1 was synthesized from 2 in three steps with 65% overall yield. Analyses of the 1H nmr data of a number of 3‐amino‐2,5‐dioxo‐2,3,4,5‐tetrahydro‐1H‐1‐benzazepine derivatives led to the conclusion that these compounds adopt a similar conformation and that this ring system is rigid. X‐ray crystallography was used to define the structure of 3, and computer‐aided energy minimization of 6 gave a preferred conformation similar to that observed in the crystal of 3. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：279 / 286

页数：8

共 37 条

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[3]

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[4]

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