INDICATIONS OF AN ADAPTIVE RESPONSE IN C57BL MICE PRE-EXPOSED INVIVO TO LOW-DOSES OF IONIZING-RADIATION

被引：72

作者：

WOJCIK, A ^{[1
]}

TUSCHL, H ^{[1
]}

机构：

[1] AUSTRIAN RES CTR SEIBERSDORF, INST BIOL, A-2444 SEIBERSDORF, AUSTRIA

来源：

MUTATION RESEARCH | 1990年 / 243卷 / 01期

关键词：

Adaptive response; Low-dose radiation; Mouse lymphocytes; Sister-chromatid exchange; Unscheduled DNA synthesis;

D O I：

10.1016/0165-7992(90)90125-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

C57BL/6 mice were whole-body irradiated with 5 cGy/day ('adapting dose') on 4 consecutive days and their spleens removed on day 1, 3, 7, 12, 19 or 26 after the last irradiation. In vitro UV-light-induced unscheduled DNA synthesis (UDS) and mitomycin C (MMC)-induced sister-chromatid exchanges (SCEs) were scored in lymphocytes (UV-light and MMC being the 'challenging agents'), yielding higher UDS values and lower frequencies of induced SCEs than cells of non-adapted animals. On day 12 this effect could only be seen in half, on days 19 and 26 in none of the performed experiments. The results support those published by Tuschl et al. (1980, 1983) and Liu et al. (1987), showing that it is possible to induce the adaptive response in vivo. © 1990.

引用

页码：67 / 73

页数：7

共 27 条

[1] VARIABILITY OF THE ADAPTIVE RESPONSE TO IONIZING-RADIATIONS IN HUMANS [J].

BOSI, A ;

OLIVIERI, G .

MUTATION RESEARCH, 1989, 211 (01) :13-17

[2] ANALYSES OF SISTER-CHROMATID EXCHANGE AND CELL-CYCLE KINETICS IN MOUSE LYMPHOCYTE-T AND LYMPHOCYTE-B FROM PERIPHERAL-BLOOD CULTURES [J].

EREXSON, GL ;

WILMER, JL ;

KLIGERMAN, AD .

MUTATION RESEARCH, 1983, 109 (02) :271-281

[3]

EVENSEN G, 1982, NATURE, V296, P773, DOI 10.1038/296773a0

[4]

Friedberg E. C., 1985, DNA REPAIR

[5] THE CURRENT EVIDENCE FOR AN ADAPTIVE RESPONSE TO ALKYLATING-AGENTS IN MAMMALIAN-CELLS, WITH SPECIAL REFERENCE TO EXPERIMENTS WITH INVITRO-CELL CULTURES [J].

FROSINA, G ;

ABBONDANDOLO, A .

MUTATION RESEARCH, 1985, 154 (02) :85-100

[6] FACTORS INVOLVED IN DIFFERENTIAL GIEMSA-STAINING OF SISTER CHROMATIDS [J].

GOTO, K ;

MAEDA, S ;

KANO, Y ;

SUGIYAMA, T .

CHROMOSOMA, 1978, 66 (04) :351-359

[7] CHROMOSOMAL RESPONSES TO IONIZING-RADIATION REMINISCENT OF AN ADAPTIVE RESPONSE IN CULTURED CHINESE-HAMSTER CELLS [J].

IKUSHIMA, T .

MUTATION RESEARCH, 1987, 180 (02) :215-221

[8] SISTER CHROMATID EXCHANGE FORMATION [J].

LATT, SA .

ANNUAL REVIEW OF GENETICS, 1981, 15 :11-55

[9] SISTER-CHROMATID EXCHANGES INDUCED BY MITOMYCIN-C AFTER EXPOSURE OF HUMAN-LYMPHOCYTES IN GO TO A LOW-DOSE OF X-RADIATION [J].

MOQUET, JE ;

LLOYD, DC ;

PROSSER, JS ;

EDWARDS, AA .

MUTATION RESEARCH, 1987, 176 (01) :143-146

[10] ADAPTATION-LIKE RESPONSE TO THE CHEMICAL INDUCTION OF SISTER CHROMATID EXCHANGES IN HUMAN-LYMPHOCYTES [J].

MORIMOTO, K ;

SATOMIZUNO, M ;

KOIZUMI, A .

HUMAN GENETICS, 1986, 73 (01) :81-85

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