INVITRO REPLICATION THROUGH NUCLEOSOMES WITHOUT HISTONE DISPLACEMENT

被引：114

作者：

BONNEANDREA, C ^{[1
]}

WONG, ML ^{[1
]}

ALBERTS, BM ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

NATURE | 1990年 / 343卷 / 6260期

关键词：

D O I：

10.1038/343719a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A well-characterized set of proteins encoded by bacteriophage T4 replicates DNA in vitro and generates replication forks that can pass nucleo-somes. The histone octamers remain associated with newly replicated DNA even in the presence of excess DNA competitor, and intact nucleosomes re-form on the two daughter DNA helices. It is concluded that nucleosomes are designed to open up transiently to allow the passage of a replication fork without histone displacement. © 1990 Nature Publishing Group.

引用

页码：719 / 726

页数：8

共 64 条

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