TUFTSIN-BEARING LIPOSOMES AS DRUG VEHICLES IN THE TREATMENT OF EXPERIMENTAL ASPERGILLOSIS

被引：31

作者：

OWAIS, M

AHMED, I

KRISHNAKUMAR, B

JAIN, RK

BACHHAWAT, BK

GUPTA, CM

机构：

[1] INST MICROBIAL TECHNOL,POB 1304,SECTOR 39-A,CHANDIGARH 160014,INDIA

[2] DELHI UNIV,LIPOSOME RES CTR,NEW DELHI 110021,INDIA

来源：

FEBS LETTERS | 1993年 / 326卷 / 1-3期

关键词：

TUFTSIN; MACROPHAGE ACTIVATION; FUNGAL INFECTION; LIPOSOME; AMPHOTERICIN-B;

D O I：

10.1016/0014-5793(93)81760-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.

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页码：56 / 58

页数：3

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